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# Structural Basis of Membrane Curvature

# Sensing by Synaptotagmin-1

*Chen K., Park J., Williams A., Zhao R. et al.*

Harvard Medical School · MIT · Broad Institute

## Abstract

We report the cryo-EM structure of synaptotagmin-1

bound to the SNARE complex at **2.3 Å** resolution.

## 1. Introduction

$$\Delta G = \sum_i \varepsilon_i \psi_i^2 - kT\ln Z$$

## Table 1 — Resolution Comparison

| Method | Resolution | FSC |

|--------|-----------|-------|

| Cryo-EM | 2.3 Å | 0.94 |

| X-ray | 3.1 Å | 0.87 |